Related Products of 16681-59-7, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 16681-59-7, name is 2-Bromo-1-methyl-1H-imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
EXAMPLE 62 (METHOD O); 6,6-Dimethyl-2-[6-(l-methyl-lH-imidazol-2-yl)-2,3-dihvdrobenzo[l,41oxazin-4-yll-6,7- dihydro [ 1 ,31 thiazolo [ 5 A-c] p yridin-4( 5H)-one; A mixture of Intermediate 66 (0.050 g, 0.14 mmol), l-methyl-2-bromoimidazole (0.067 g, 0.4 mmol), tetra-n-butylammonium bromide (0.135 g, 0.4 mmol), Na2CO3 (0.045 g, 0.4 mmol), tetrakis(triphenylphosphine)palladium(0) (0.016 g, 0.014 mmol) and water (1 mL) in TetaF (3 mL) was heated to 1400C under microwave irradiation for 20 minutes. Additional portions of l-methyl-2-bromoimidazole (0.033 g, 0.2 mmol) and tetrakis(triphenylphosphine)palladium(0) (0.016 g, 0.014 mmol) were added, and heating continued for a further 40 minutes. After cooling to r.t., the reaction mixture was concentrated in vacuo, and the residue partitioned between DCM (50 mL) and water (50 mL). The organic fraction was washed with water (50 mL) and brine (50 mL), dried (MgSO4), filtered and concentrated in vacuo. The crude material was purified by preparative etaPLC (Method 6) to give the title compound (0.002 g, 4%) as a white solid. deltaeta (CDCl3) 8.18 (IH, d, J 1.9 Hz), 7.33 (IH, dd, J8.5 and J 1.9 Hz), 7.02 (IH, d, J 1.3 Hz), 6.98 (IH, d, J 8.5 Hz), 6.89 (IH, d, J 1.1 Hz), 5.10 (IH, br. s), 4.36-4.29 (2H, m), 4.12-4.04 (2H, m), 3.74 (3H, s), 2.80 (2H, s), 1.32 (6H, s). LCMS (ES+) 396.0 (M+H)+, RT 1.66 minutes (Method I).
The synthetic route of 2-Bromo-1-methyl-1H-imidazole has been constantly updated, and we look forward to future research findings.
Reference:
Patent; UCB PHARMA S.A.; WO2008/1076; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem