Reference of 1964-77-8, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1964-77-8, name is 5-Bromo-2-methyl-1H-benzo[d]imidazole, This compound has unique chemical properties. The synthetic route is as follows.
Example 90:2-Methyl-5-[4-(methylsuIfonylmethyl)-6-morphoIin-4-yI-pyrimidin-2-yl]-lJfiT- benzoimidazoleA mixture of 5-bromo-2-methyl-lH-benzoimidazole (250 mg), potassium acetate (349 mg) and bis(pinacolato)diboron (362 mg) in 1,4-dioxane (10 niL) was degassed for 5 minutes. l,r-Bis(diphenylphosphino)ferrocenedichloropalladium(II) dichloromethane adduct (59 mg) was added and the reaction was heated to 8O0C for 18 hours. 2-Chloro-4- (methylsulfonylmethyl)-6-morpholin-4-yl-pyrimidine (346 mg), ethanol (0.75 mL), a 2M solution of sodium carbonate (2.7 mL) and additional 1,1′- bis(diphenylphosphino)ferrocenedichloiOpalladium(II) dichloromethane adduct (59 mg) were added and the heating was continued for a further 3 hours. The cooled reaction mixture was concentrated in vacuo, dissolved in methanol and loaded onto a SCX-2 column (10 g). The column was washed with methanol and the compound removed with 7N ammonia in methanol. The solution was concentrated in vacuo and the residue chromatographed by prep-HPLC (basic) to give the desired compound as a grey solid (5 mg).Mass Spectrum; MH+ 388.
The chemical industry reduces the impact on the environment during synthesis 5-Bromo-2-methyl-1H-benzo[d]imidazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/80382; (2007); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem