Electric Literature of 28890-99-5, A common heterocyclic compound, 28890-99-5, name is 5H-Benzo[d]benzo[4,5]imidazo[1,2-a]imidazole, molecular formula is C13H9N3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A.) 10.6 g ( 41 .6 mmol) 2-bromo-6-fluoro-benzonitrile, 8.63 g (41.6 mmol) 6H- benzimidazolo[1 ,2-a]benzimidazole and 30.9 (146 mmol) potassium phosphate tribasic in 70 ml NMP (N-Methyl-2-pyrrolidon) are stirred at 1 15 C under nitrogen for 2 h. The reaction mixture is filtered hot and the or organic phase is poured on water. The product is filtered of. Yield 17 g (94 %). 1H NMR (300 MHz, DMSO-D6): delta 8.22-8.34 (m, 3H), 8.02-8.05 (m, 1 H), 7.69-7.79 (m, 1 H), 7.60-7.65 (m, 1 H), 7.30-7.50 (m, 5H)
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; IDEMITSU KOSAN CO., LTD.; RAIMANN, Thomas; SCHAeFER, Thomas; SAITO, Masatoshi; WOLLEB, Heinz; BENEDITO, Flavio Luiz; NISHIMAE, Yuichi; NAKANO, Yuki; NAGASHIMA, Hideaki; (111 pag.)WO2016/157113; (2016); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem