Application of 45676-04-8,Some common heterocyclic compound, 45676-04-8, name is 1-tert-Butylimidazole, molecular formula is C7H12N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
General procedure: 1-substituted 3-allylimidazolium chloride (2 mmol) was dissolved in 25 mL of dichloromethane and transferred into a Schlenk vessel. Excess Silver(I) oxide (1.5 mmol) was added, and the mixture was stirred for24 h at room temperature under argon atmosphere [19]. Then the unreactedAg2O was filtered through a plug of Celite. The resulting solution was filtered through celite, solvent was evaporated in vaccuo,washed with diethylether (2 mL×2) and dried in vacuo.[RuBr2(PPh3)3] (1 g, 1 mmol) was taken up in 5 mL of dichloromethane and added to a solution of Ag complex in 10 mL of CH2Cl2. The mixture was stirred overnight at room temperature. After filtration in air, the solvent was removed in vacuum to give the product. The final compound is stable in air. Single crystals of the compound 3a were achievedby slow evaporation of a concentrated solution in a mixture of dichloromethane and acetone.
The synthetic route of 45676-04-8 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Nirmala, Muthukumaran; Murugan, Kaliyappan; Vijayapritha, Subbarayan; Viswanathamurthi, Periasamy; Bertani, Roberta; Malecki, Jan Grzegorz; Inorganica Chimica Acta; vol. 486; (2019); p. 55 – 62;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem