73746-45-9, name is 5-Iodo-2-methyl-1H-imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Application In Synthesis of 5-Iodo-2-methyl-1H-imidazole
4-IODO-2-METHYL-LH-IMIDAZOLE (200 mg, 1.0 mmol), 4-fluorophenylboronic acid (215 mg, 1.6 mmol), copper (II) acetate (210 mg, 1.2 mmol) and ET3N (0.16 ml, 1.2 mmol) were sus- pended in 10 ml THF and oxygen was bubbled through the reaction mixture for 40 min. The reaction mixture was stirred for 48 hours at RT and then filtrated over DICALIT. The filtrate was concentrated and then purified by flash chromatography to yield 1- (4-FLUORO- PHENYL)-4-IODO-2-METHYL-LH-IMIDAZOLE (120 mg, 0.40 mmol, 41 %).
The synthetic route of 73746-45-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/80998; (2004); A1;,
Imidazole – Wikipedia,
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