Adding a certain compound to certain chemical reactions, such as: 137049-00-4, name is 1-Methyl-1H-imidazole-4-sulfonyl chloride, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 137049-00-4, HPLC of Formula: C4H5ClN2O2S
(1-Methylimidazol-4-yl)sulfonyl chloride (23 mg, 0.13 mmol) was added dropwise to a stirred solution of 3-[4-(2-ethyl-5-methyl-2H-pyrazol-3-yl)piperidin-1-yl]-1-phenylpropylamine (see Example 8) (48 mg, 0.15 mmol) and Et3N (20 muL, 0.14 mmol) in CH2Cl2 (2 mL) at RT under N2. The mixture was stirred for 18 h, then was diluted with CH2Cl2 (20 mL) and washed with NaHCO3 solution (20 mL). Then the organic layer was separated and the aqueous phase was re-extracted with CH2Cl2 (20 mL) and the combined organic extracts dried (MgSO4), and concentrated under reduced pressure. The residue was taken up in Et2O (5 mL) and purified by trituration. The title compound (55 mg, 56%) was isolated as a colourless solid. 1H NMR (d6-DMSO, 400 MHz) delta8.28 (1H, d, J=7.8 Hz), 7.68 (1H, s), 7.54 (1H, s), 7.26-7.14 (5H, m), 5.81 (1H, s), 4.35-4.25 (1H, m), 3.93 (2H, q, J=7.2 Hz), 3.60 (3H, s), 2.75-2.50 (3H, m), 2.09 (3H, s), 2.08-2.00 (2H, m), 1.95-1.40 (8H, m), 1.27 (3H, t, J=7.2 Hz). MS (ES+) C24H34N6O2S requires: 470, found: 471 (1:1, M+H+).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-Methyl-1H-imidazole-4-sulfonyl chloride, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Chambers, Mark Stuart; Jones, Philip; Szekeres, Helen Jane; US2004/2504; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem