Related Products of 3012-80-4, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 3012-80-4 as follows.
To a mixture of thiazolidinedione (6a, 0.5mmol), 1-methyl-1H-benzo[d]imidazole-2-carbaldehydes (10a, 0.55mmol) in ethanol (4mL) was added catalytic amount of piperidine. The reaction mixture was refluxed until complete conversion as observed by TLC. After cooling, the precipitates were filtered, washed and recrystalized with ethanol, to obtain pure (Z)-5-((1-methyl-1H-benzo[d]imidazol-2-yl)methylene)-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)thiazolidine-2,4-dione derivative 11a as yellow solids. All the other compounds 11b?t were obtained in a similar reaction procedure of 11a in moderate to high yields. 5.1.1 (Z)-5-((1-Methyl-1H-benzo[d]imidazol-2-yl)methylene)-3-(2-oxo-2-(pyrrolidin-1-yl)ethyl)thiazolidine-2,4-dione (11a) Yellow solid, Yield 82percent; mp: 264?266°C; FT-IR: (cm?1): 2985, 2964, 1740, 1679, 1659, 1385, 1220, 750; 1H NMR (500MHz, DMSO-d6): delta 7.99 (s, 1H), 7.78 (d, J=8.1Hz, 1H), 7.69 (d, J=8.1Hz, 1H), 7.39 (t, J=7.9Hz, 1H), 7.32 (t, J=7.5Hz, 1H), 4.50 (s, 2H), 4.02 (s, 3H), 3.55 (t, J=6.6Hz, 2H), 3.31 (t, J=7.3Hz, 2H), 1.97?1.89 (m, 2H), 1.84?1.77 (m, 2H); 13C NMR (125MHz, DMSO-d6): delta 169.6, 164.8, 162.6, 147.3, 142.6, 135.8, 128.1, 124.2, 123.1, 119.6, 116.7, 111.0, 45.7, 45.0, 42.7, 29.8, 25.8, 23.6; HRMS (ESI): m/z calcd for [M+H]+ C18H19N4O3S 371.1178; found 371.1171.
According to the analysis of related databases, 3012-80-4, the application of this compound in the production field has become more and more popular.
Reference:
Article; Sharma, Pankaj; Srinivasa Reddy; Thummuri, Dinesh; Senwar, Kishna Ram; Praveen Kumar, Niggula; Naidu; Bhargava, Suresh K.; Shankaraiah, Nagula; European Journal of Medicinal Chemistry; vol. 124; (2016); p. 608 – 621;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem