Reference of 16681-56-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 16681-56-4, name is 2-Bromo-1H-imidazole, This compound has unique chemical properties. The synthetic route is as follows.
20 g (0.136 mmol) of 2-bromo-lH-imidazole and 3.9 g (0.163 mmol) of sodium hydride were dissolved in 500 ml of THF in a round-bottomed flask, and the solution was stirred and refluxed under a nitrogen stream for one hour. Then, 40.5 g (0.217 mmol) of 3-(2-bromoethyl)pyridine was added thereto in a dropwise fashion, and the mixture was stirred and refluxed for 3 hours. When the reaction was complete, sodium hydride remaining therein was quenched by methanol. After separating an organic layer and an aqueous layer, a solvent therein was all removed. Subsequently, a resultant therefrom was treated through column chromatography, obtaining 23 g of an intermediate compound-15 (a yield: 67%).
The chemical industry reduces the impact on the environment during synthesis 2-Bromo-1H-imidazole. I believe this compound will play a more active role in future production and life.
Reference:
Patent; CHEIL INDUSTRIES INC.; KIM, HYUN JUNG; CHAE, MI YOUNG; LEE, NAM HEON; HUH, DAL HO; KIM, WOOK; KIM, YOUN HWAN; KIM, JUN SEOK; LEE, SANG IL; LEE, HYUN GYU; JANG, CHUN KEUN; JUNG, JU YEON; (32 pag.)KR2015/66887; (2015); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem