In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 1072-84-0 as follows. Safety of 1H-Imidazole-4-carboxylic acid
To a solution containing Intermediate 54 (0. 041g) in N, N-DIMETHYLFORMAMIDE (3ML) were added imidazole-4-carboxylic acid (0. 012g, ALDRICH), (1H-1, 2, 3-benzotriazol-1-yloxy) (TRI-1- pyrrolidinyl) phosphonium hexafluorophosphate (PyBop) (0. 053g) and N, N- diisopropylethylamine (0. 03ML). The solution was stirred under nitrogen at room temperature for 18h and was then concentrated in vacuo. The residual gum was purified using an aminopropyl SPE cartridge eluting with methanol followed by chromatography on silica gel (SPE cartridge), eluting with a gradient of 0% to 8% methanol in chloroform, to give the title compound as a yellow solid (0. 031g). LC/MS Rt 2. 32 min, M/Z 549 [MH+]
According to the analysis of related databases, 1072-84-0, the application of this compound in the production field has become more and more popular.
Reference:
Patent; GLAXO GROUP LIMITED; WO2004/103998; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem