Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 1402838-08-7, name is 2-(1-Trityl-4-imidazolyl)benzaldehyde, A new synthetic method of this compound is introduced below., Application In Synthesis of 2-(1-Trityl-4-imidazolyl)benzaldehyde
A solution of compound 5-d (166 mg, 1.2 mmol), ethanol in ethanol (20%, 0.6 mL, 1.55 mmol) was added to a solution ofTo a solution of compound 5-e (see patent: WO2012142237 method) (500 mg, 1.2 mmol) in tetrahydrofuran (6 mL)in. The reaction mixture was stirred overnight at room temperature and saturated aqueous ammonium chloride (5 mL) was added. The reaction mixture was washed with acetic acidEthyl ester (2 x 20 mL). The organic phases were combined, washed with saturated brine (10 mL), dried over anhydrous sodium sulfate, concentrated under reduced pressure,Compound 5-c (671 mg) was used directly in the next step.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; Shanghai Yingli Pharmaceutical Co., Ltd.; Xu Zusheng; Lou Yangtong; Wu Tianzhi; (87 pag.)CN106478634; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem