Some common heterocyclic compound, 288-32-4, name is 1H-Imidazole, molecular formula is C3H4N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: imidazoles-derivatives
(1) the addition of water in the reactor 10 kg, the previous batch filtrate 8 kg (filtrate all recovery use, so there is no discharge), imidazole 2.6 kg, potassium hydroxide 3.9 kg, batchwise by adding bromine 4.8 kg, canada finishes, controlled to disappear in the raw materials, the reaction temperature is controlled in the 80 – 90 C). Adding concentrated hydrochloric acid to adjust the pH to 7 the left and right, a large quantity of solid precipitate (mostly 4 – bromo – 1H – imidazole and a little double bromine substituted imidazole). Filtering after-filtration cake (4.3 kg, yield 90%) can be directly into the next step of the reaction, the filtrate as the solvent directly used in the next batch (non-sewage disposal).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 288-32-4, its application will become more common.
Reference:
Patent; Hangzhou Lide Biological Technology Co., Ltd.; Ren Guobao; Wu Yan; Li Chuanbin; (5 pag.)CN106674121; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem