Application of 39021-62-0,Some common heterocyclic compound, 39021-62-0, name is 1-Methyl-1H-imidazole-5-carbaldehyde, molecular formula is C5H6N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
To a solution of l-methyl-lH-imidazole-5-carboxaldehyde (500 mg, 4.45 mmol) in tetrahydrofuran (5 ml), 4-fluorophenylmagnesium bromide (1.0 M solution in tetrahydrofuran, 6.20 ml, 6.20 mmol) was added dropwise at 0 C over 5 minutes andstirred at 0 C for 30 minutes. The reaction was quenched with saturated aqueousNH4CI solution (30 ml), extracted with chloroform (50 ml x 3), dried (MgSO4) and evaporated under reduced pressure. The residue was purified by column chromatography on silica (ethyl acetate/methanol, 100/0-90/10) to give (4- fluorophenyl)(l -methyl- lH-imidazol-5-yl)methanol (443 mg, 48 %, colorless solid).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-Methyl-1H-imidazole-5-carbaldehyde, its application will become more common.
Reference:
Patent; SHIONOGI & CO., LTD.; EURO-CELTIQUE S.A; WO2008/8398; (2008); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem