Synthetic Route of 144690-33-5, The chemical industry reduces the impact on the environment during synthesis 144690-33-5, name is Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate, I believe this compound will play a more active role in future production and life.
In the equipped with electric stirrer, condenser and a thermometer of the 500 ml three-necked flask, add 20.00g (27.93mmol) intermediate I, 3.13g (55.87mmol) KOH and 80g acetone, for 55 C stirring for 3 hours (TLC monitoring), after the stop of the reaction, to cool down to 20 – 30 C, concentrated to no longer under the dripped, for 1M hydrochloric acid to adjust the pH=3, a large number of white solid precipitated, stirring at the room temperature 1 – 2h, filtering, the filter cake drying added 60 ml ethyl acetate at room temperature beating, filtering, the filter cake is dried to obtain the 11.50g impurities (see Figure 3) F, HPLC: 98.55%, yield: 59.77%.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Ethyl 4-(2-hydroxypropan-2-yl)-2-propyl-1-((2′-(1-trityl-1H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-1H-imidazole-5-carboxylate, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; Tsingtao Yellow Sea Pharmaceutical Co., Ltd.; Liu Chuanfei; Chen Xiaotao; Li Yanshun; Wang Jiahui; Liu Ningning; Yang Kebao; (15 pag.)CN106831727; (2017); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem