Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 38993-84-9, name is (1-Methyl-1H-imidazol-5-yl)methanol, A new synthetic method of this compound is introduced below., category: imidazoles-derivatives
Step 2: Intermediate 34-c To a solution of (l-methyl-lH-imidazol-5-yl) methanol (3.1 g, 27.6 mmol) and intermediate 34-b (4.01 g, 23.04 mmol) in toluene (25.0 ml) and DMPU (25.0 ml) was added sodium 2-methylpropan-2-olate (4.43 g, 46.1 mmol). The reaction was stirred overnight at 80 °C and then cooled to room temperature. A saturated aqueous solution of ammonium chloride and ethyl acetate were added, the organic layer was separated, washed twice with a saturated aqueous solution of ammonium chloride and brine, dried over MgS04, filtered and concentrated in vacuo. Purification by silica gel chromatography provided intermediate 34-c as beige oil.
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; PHARMASCIENCE, INC.; LAURENT, Alain; ROSE, Yannick; JAQUITH, James B.; WO2013/177668; (2013); A1;,
Imidazole – Wikipedia,
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