Reference of 14741-71-0, A common heterocyclic compound, 14741-71-0, name is Ethyl 2-(1H-benzo[d]imidazol-2-yl)acetate, molecular formula is C11H12N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A solution of 4.08 g (20 mmol) compound 2 in glacial acetic acid (30 mL) wasadded dropwise to 45 % aqueous sodium nitrite solution (10 mL, 65 mmol) at0-5 8C under a nitrogen atmosphere. The reaction mixture was stirred at 20 8C for2 h then poured into ice-water and neutralized with saturated sodium carbonatesolution. The precipitate was isolated by filtration, washed with water, and vacuumdried. The solid obtained was recrystallized from methanol-diethyl ether (2:1 v/v) togive compound 3 (3.34 g; yield 72 %) as pale yellow crystals, m.p. 152.3-153.9 8C. 1H NMR (400 MHz, CDCl3) d: 1.44-1.49 (t, J = 7.2 Hz, 3H, CH3), 4.47-4.53 (q,J = 7.2 Hz, 2H, CH2), 7.26-7.69 (m, 4H, ArH), 11.06 (s, 1H, OH). IR (KBr) m(cm-1): 3416 (N-H), 3258 (O-H), 3070 (Ar-H), 1714 (C=O), 1622 (C=N), 1279,1043 (C(O)-O-C). ESI-MS m/z: calcd for C11H11N3O3 [M ? Na]? 256.2, obsd[M ? H]? 256.4.
The synthetic route of 14741-71-0 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Zhang, Peizhi; Wan, Fuxian; Li, Ying; Li, Chengkun; Jiang, Lin; Research on Chemical Intermediates; vol. 41; 6; (2015); p. 3349 – 3357;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem