These common heterocyclic compound, 57090-88-7, name is 1H-Imidazole-4-carbonitrile, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: imidazoles-derivatives
4-Cyanoimidazole (2.4 g, 25.9 mmol), KF-alumina (8 g), and iodomethane (15 mL, 240 mmol) were mixed and stirred at room temperature for 24 hours. After adding acetone (45 mL), it is stirred for 30 minutes and the solid is filtered off. After collecting the filtrate and blowing the solvent, the organic layer obtained by extraction with ethyl acetate and water is dehydrated with sodium sulfate, the solid is filtered off and the organic solvent is blown off. The reaction mixture was purified using silica gel column chromatography to obtain compound (3) (1.9 g, 17.7 mmol)This is obtained in 30% yield.
The synthetic route of 1H-Imidazole-4-carbonitrile has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Samsung Electronics Co., Ltd.; Cheil Industries Inc.; Pusan National University Institute for Research & Industry Cooperation; Noh Chang-ho; Yoon Ung-chan; Kwon O-hyeon; Choi Byeong-gi; (23 pag.)KR102046153; (2019); B1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem