Related Products of 86604-86-6, These common heterocyclic compound, 86604-86-6, name is 2-Chloro-6-(trifluoromethyl)benzimidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 9: 3-(3,4-Dichlorophenyl)-8-[5-(trifluoromethyl)-1 H-benzimidazol-2-yl1-1 -oxa-3,8- diazaspiro[4.51decan-2-one; 2-Chloro-5-(trifluoromethyl)-1 /-/-benzimidazole (Intermediate 1 , 100 mg, 0.45 mmole) and 3-(3,4-dichlorophenyl)-1-oxa-3,8-diazaspiro[4.5]decan-2-one hydrobromide (Intermediate 16, 190.5 mg, 0.498 mmol) were dissolved in a mixture of 2-pentanol:CH3CN (4:1 , 2 ml) in a vial for microwave reactions, DIPEA was added (235.1 mul, 1.35 mmol) and the mixture was heated at 200 C for 10 minutes. The mixture was concentrated under vacuum; the crude was purified by MDAP, then the fractions were collected and purified by ion- exchange SCX to give the title compound (35.4 mg, 16%). 1 H-NMR (500MHz, CDCI3): delta 1.89-2.04 (4H, m), 3.57-3.66 (2H, m), 3.76-3.87 (2H, m), 3.95 (2H, s), 7.20-7.51 (3H, m), 7.54-7.59 (1 H, m), 7.63-7.69 (1 H, d), 7.84-7.86 (1 H, d), 11.79 (1 H, br s); MS: m/z 485 [M+H]+.
Statistics shows that 2-Chloro-6-(trifluoromethyl)benzimidazole is playing an increasingly important role. we look forward to future research findings about 86604-86-6.
Reference:
Patent; GLAXO GROUP LIMITED; WO2008/129007; (2008); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem