Adding a certain compound to certain chemical reactions, such as: 870837-18-6, name is 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 870837-18-6, Safety of 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde
To a solution of the thus obtained 3-methoxy-4-(4-methylimidazol-1-yl)benzaldehyde (4.00 g) in tetrahydrofuran (40 mL), diethylphosphonoacetic acid ethyl ester (4.00 mL) and lithium hydroxide monohydrate (932 mg) were added sequentially, and the reaction mixture was stirred overnight. After confirming the disappearance of the starting materials, 2N aqueous sodium hydroxide (30 mL) and ethanol (5 mL) were added to the reaction mixture, which was then stirred overnight at room temperature. The reaction mixture was cooled to 0 C., followed by addition of 2N hydrochloric acid (30 mL). The resulting precipitates were collected using a Kiriyama funnel and washed with water and ethyl acetate to give (E)-3-[3-methoxy-4-(4-methylimidazol-1-yl)phenyl]acrylic acid (4.61 g). The physical property data of the resulting compound are as shown below. 1H-NMR (DMSO-d6) delta (ppm): 7.81 (s,1H), 7.60 (d,J=16 Hz,1H), 7.56 (s,1H), 7.39 (d,J=8.0 Hz,1H), 7.35 (d,J=8.0 Hz,1H), 7.16 (s,IH), 6.66 (d,J=16 Hz,1H), 3.88 (s,3H), 2.15 (s,3H).
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Reference:
Patent; Eisai Co., Ltd.; US2006/241038; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem