Related Products of 93-84-5, A common heterocyclic compound, 93-84-5, name is 5-Nitro-1H-benzo[d]imidazol-2(3H)-one, molecular formula is C7H5N3O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Concentrated hydrochloric acid (5 drops) was added to a suspension of 5-nitro-1, 3-dihydrobenzimidazol-2-one (intermediate 10,0. 96g) in phosphorus oxychloride (25ml) and the mixture was stirred and heated at reflux for 7h. The cooled mixture was poured into a mixture of ice and water and the precipitated product was extracted into ethyl acetate. The organic phase was dried (MgSO4), filtered and the filtrate was evaporated to give 2-chloro-5-nitrobenzimidazole as a tan coloured solid (0.9g). ‘H NMR (DMSO-d6) d 14.0 (brs, 1H) 8.45 (brs, 1H) 8.15 (d, 1H) 7.7 (d, 1H)
The synthetic route of 93-84-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ARGENTA DISCOVERY LTD.; WO2005/35526; (2005); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem