Related Products of 152628-02-9, These common heterocyclic compound, 152628-02-9, name is 1,7′-Dimethyl-2′-propyl-1H,1’H-2,5′-bibenzo[d]imidazole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under the stream of nitrogen, the 4-methyl-6-(1-methyl-1H- benzimidazole-2-yl)-2-propyl-1H-benzimidazole of 50g was added to and stirred in isopropanol of 150ml and dimethyl sulfoxide of 50ml and potassium t-butoxide of 20.28g were added thereto, slowly heated, and stirred at 40~45C for 1 hour. The reaction mixture was cooled to 30~35C and the methyl 2-[4-(bromomethyl) phenyl] benzoate of 55.14g was added into the reaction mixture, which was stirred for 6 hours. The purified water of 250ml was added into the mixture and stirred at 20~25C for 1 hour. The resulting crystals were filtered and sequentially washed with purified water of 50ml and acetone of 50ml and dried to obtain the methyl 2-(4-{[4-methyl-6-(1-methyl-1H- benzimidazole-2-yl)-2-propyl-1H- benzimidazole-1-yl]methyl}phenyl)benzoate of 82.58g (yield of 95.1%).[88] m/e 528.6(parent ion); 1H NMR(DMSO-d6) delta0.99(t, 3H, J=7.24Hz), 1.73~1.88(m, 2H), 2.64(s, 3H), 2.92(t, 2H, J=7.42Hz), 3.50(s, 3H), 3.84(s, 3H), 5.64(s, 2H), 7.12~7.32(m, 6H), 7.33~7.82(m, 8H)
The synthetic route of 152628-02-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; DONG WHA PHARM. CO., LTD.; OH, Yoon-Seok; LIM, Jae-Kyung; CHOI, Jung-Uk; KWON, O-Jin; LEE, Jun-Sang; WO2011/102645; (2011); A2;,
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