Application of 2466-76-4, The chemical industry reduces the impact on the environment during synthesis 2466-76-4, name is 1-(1H-Imidazol-1-yl)ethanone, I believe this compound will play a more active role in future production and life.
To a suspension of 60percent sodium hydride (71.1mg, 1.78 mrnol) in DMSO (1.8 rnL)was added 6-brorno-3,4-dihydronaphthalen-2( H)-one (200 mg, 0.889 mmol). Then. 1-(1H-imidazol-i-vi)ethanone (117 mg, 107 mmoi) was added. The reaction was stirred at rt for 20 miii The reaction was diluted with EtOAc, washed with iN HC1 and brine, dried over MgSO4. It was filtered and concentrated. Purification by flash chromatography (24 g column, 0-40percent EtOAc in Hexanes) afforded intermediate 3A as a pale yellow solid (163mg, 69percent). ?H NMR (400 MHz, CHLOROFORM-d) 5 7.32 7.24 (in, 2H), 6.97 (d, J=9.0 Hz, 11-1), 2.80 – 2.71 (m, 21-1), 2.51 242 (in, 2H), 2.28 (s, 3H). LCMS [M + FIj 268.9.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(1H-Imidazol-1-yl)ethanone, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; YANG, Wu; GLUNZ, Peter, W.; BHIDE, Rajeev, S.; THIYAGARAJAN, Kamalraj; (83 pag.)WO2018/102325; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem