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The chemical industry reduces the impact on the environment during synthesis Methyl benzimidazole-5-carboxylate. I believe this compound will play a more active role in future production and life.

Synthetic Route of 26663-77-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 26663-77-4, name is Methyl benzimidazole-5-carboxylate, This compound has unique chemical properties. The synthetic route is as follows.

Step 1: A mixture of compound 1 (520 mg, 3 mol) and 2M NaOH (5 ml) in MeOH (10 ml) and THF (10 ml) was stirred 70C for overnight. TLC was used to monitor the reaction. The mixture was then concentrated to a residue, added water (30mL) and used citric acid to adjust PHto 5-6. Extracted with EA, the organic layer was separated, washed, dried, filtered and concentrated to get compound 4 as yellow solid (320 mg, 67%)

The chemical industry reduces the impact on the environment during synthesis Methyl benzimidazole-5-carboxylate. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ACETYLON PHARMACEUTICALS, INC.; VAN DUZER, John, H.; MAZITSCHEK, Ralph; WO2014/121062; (2014); A1;,
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