Synthetic Route of 570-22-9, These common heterocyclic compound, 570-22-9, name is 1H-Imidazole-4,5-dicarboxylic acid, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a dried f[ask, to 25 g (157 mmo[) 1H-imidazo[e-4,5-dicarboxy[ic acid in 334 mL of to[uene, 12.1 mL DMF and 94 mL (1.29 mo[) thiony[ ch[oride were added. The mixture was stirred for 24 h at 80C.The mixture was concentrated under reduced pressure. 100 mL to[uene were added and the mixture was concentrated under reduced pressure to give 35.5 g of thetit[e compound as crude materia[ which was used at the same day without further purification for subsequent steps.
The synthetic route of 570-22-9 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BAYER PHARMA AKTIENGESELLSCHAFT; EIS, Knut; ACKERSTAFF, Jens; WAGNER, Sarah; BASTING, Daniel; GOLZ, Stefan; BENDER, Eckhard; LI, Volkhart Min-Jian; LIENAU, Philip; LIU, Ningshu; SIEGEL, Franziska; BAUSER, Marcus; SUeLZLE, Detlev; HOLTON, Simon; BAIRLEIN, Michaela; BUCHGRABER, Philipp; BALINT, Jozsef; WO2015/150449; (2015); A2;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem