In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 870837-18-6 as follows. name: 3-Methoxy-4-(4-methyl-1H-imidazol-1-yl)benzaldehyde
Compound B2 (R2 = H, 1.5 g, 5.6 mmol, synthesized as in Tett. 1987, 43, 5125) in 40 ml of anhydrous THF at 0 0C was treated with NaH (0.25 g, 5.9 mmol, 60% in mineral oil). After 20 min, B1 (R8 = H, R10 = 3-MeO-Phenyl, R9 = 4-(4- Methylimidazol-1-yl), 1.Og, 4.62 mmol) was added and the reaction warmed to ambient temperature. After 18 h, the reaction mixture was quenched with saturated aqueous NH4CI and extracted with EtOAc (2x). The combined organic layers washed with saturated aqueous NaHCO3, brine, dried over MgSO4 and concentrated in vacuo. Flash chromatography (gradient 1? 10 % MeOH/CH2CI2) provided 1.2 g (81 %) of B3 (R8 = H, R2 = H, R10 = 3-MeO-Phenyl, R9 = 4-(4-Methyl-imidazol-1-yl)).
According to the analysis of related databases, 870837-18-6, the application of this compound in the production field has become more and more popular.
Reference:
Patent; SCHERING CORPORATION; WO2009/20579; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem