288-32-4, name is 1H-Imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. COA of Formula: C3H4N2
(2)Take a concentration of 20% sodium hydride in DMF, under icecooling,to 2ml / s Was added dropwise with stirring speedof 20% of the concentration of imidazole in DMF, the reaction was stirred at 60 C 60min, after cooling in an ice salt bathmethod, was slowly added to the intermediate product 1, the sodium hydride Of DMF, imidazole in DMF and the weight ratioof the intermediate product as a 7: 7: 5 stirred at 60 C in 120min reaction mix, after cooling in an ice salt bath method, areaction solution adding to said reaction mixture 25% by weight of nhexanewas accounted for the reaction, at a speed of 3rev / sec After stirring for 15min, plus The reaction solution into account the 350% by weight of the ice, with 3 rev / sec stirreduntil evolution ceased Shen After the precipitate was filtered, the filter cake with accounting for 1/3 times the weight of thefilter cake was washed with water once, in order to speed 2830r / min Conditions centrifugal drying 60min, with the centrifugalaccounted for 2.5 times the weight of the resulting product was dried and 0.05 Times with ethyl acetate and activated carbon,was allowed to stand at 5 C was recrystallized from 13 hours, 50 C and By recrystallization of the obtained product wasdried to obtain intermediate 2 detected by HPLC. Intermediate 2 71.5% yield, wherein the desired product 1(2hydroxy4(4chlorophenyl)butanoic Yl) 1Hydrogen imidazolecontent was 99.31 percent
The synthetic route of 288-32-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; zhuzhou qianjin Pharmaceutical Co., Ltd.; Li, fu Jun; Peng, Kaifeng; wen, fengqiu; li, yonggen; li, sanxin; gong, yun; (16 pag.)CN105218455; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem