These common heterocyclic compound, 10111-08-7, name is Imidazole-2-carboxaldehyde, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Recommanded Product: 10111-08-7
To a solution of tert-butyl 2-bromoacetate (19.5 g, 100 mmol), 1H-imidazole-2-carbaldehyde (9.6 g, 100 mmol) in anhydrous DMF (50 mL) was added KI (4.98 g, 30 mmol) and DIPEA (26 mL, 150 mmol). The reaction mixture was stirred at 80 ?C under nitrogen for 5 h. After the solvent was evaporated under reduced pressure, the reaction mixture was diluted with DCM, washed with water and dried. Solvent was evaporated under reduce pressure to afford a residue, which was purified using a Biotage SP4 over silica gel and eluted with DCM to 6% methanol in DCM to 3a (17.30 g, 82%). 1H NMR (400 MHz, CDCl3) ? 9.78 (s, 1 H), 7.31 (s, 1 H), 7.12 (s, 1 H), 5.01 (s, 2 H), 1.46 (s, 9 H); MS (ESI), 211 (M+H)+.
The synthetic route of Imidazole-2-carboxaldehyde has been constantly updated, and we look forward to future research findings.
Reference:
Article; Lu, Genliang; Maresca, Kevin P.; Hillier, Shawn M.; Zimmerman, Craig N.; Eckelman, William C.; Joyal, John L.; Babich, John W.; Bioorganic and Medicinal Chemistry Letters; vol. 23; 5; (2013); p. 1557 – 1563;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem