Application of 614-97-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 614-97-1, name is 5-Methyl-1H-benzo[d]imidazole belongs to imidazoles-derivatives compound, it is a common compound, a new synthetic route is introduced below.
5-methyl-i H-i ,3-benzodiazole (0.5 g, 7.6 mmol), Boc anhydride (2.44 g, ii .4 mmol), DMAP (92 mg, 0.76mmol) and triethylamine (2.11 mL, iSmmol) were dissolved in acetonitrile (10 mL). The mixture was stirred at 80C overnight, cooled and solvent was removed in vacuo. Crude product was purified via column chromatography using DCM as eluent. Fractions containing the title compound were combined and concentrated (0.80 g, 46%). UPLC (254nm): RT=3.75 mm, 93.2% purity, [M+H]=233.2.
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 5-Methyl-1H-benzo[d]imidazole, other downstream synthetic routes, hurry up and to see.
Reference:
Patent; PROBIODRUG AG; HEISER, Ulrich; HOFFMANN, Torsten; LUES, Ingeborg; MEYER, Antje; (248 pag.)WO2018/178384; (2018); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem