In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 71759-88-1 as follows. Safety of 5-Iodo-1-methyl-1H-imidazole
In a 10 mL two-necked flask, 5-iodo-1-methyl-1H-imidazole (150 mg, 721 mumol, Eq: 1.00) was combined with DCM (3 ml) to give a colorless solution. Ethylmagnesium bromide (264 mul, 793 mumol, Eq: 1.1) was added at rt over 2 min (white precipitate). After stirring for 1 hr, the reaction mixture was cooled to 0 C., and a solution of 4-chlorobenzaldehyde (132 mg, 937 mumol, Eq: 1.3) in DCM (2 ml) was added dropwise, and the mixture was stirred at rt. TLC after 2 h indicated the absence of starting material. Work up: The reaction mixture was quenched with sat. NaHCO3 (10 mL) and extracted with AcOEt (2*20 mL). The organic layers were washed with H2O/NaCl sol., the organic layers were combined, dried over Na2SO4, and concentrated i. V. The product was precipitated from DCM, filtered and dried on h. V. MS (ESI): 223.1/225.0 [M+H]+.
According to the analysis of related databases, 71759-88-1, the application of this compound in the production field has become more and more popular.
Reference:
Patent; HOFFMANN-LA ROCHE INC.; Aebi, Johannes; Amrein, Kurt; Hornsperger, Benoit; Kuhn, Bernd; Maerki, Hans P.; Mayweg, Alexander V.; Mohr, Peter; Tan, Xuefei; US2014/128429; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem