Synthetic Route of 46006-36-4,Some common heterocyclic compound, 46006-36-4, name is 1H-Benzimidazole-7-carboxylic acid, molecular formula is C8H6N2O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 94N-CCls^sJ^-Cl-CS’-CCCSS^RJ-S^-dimethylpiperazin-l-yOmethyO^’-hydroxybiphenyl-S- yloxy)-5-fluoronicotinamido)cyclohexyl)-lH-benzo[d]imidazole-4-carboxamide To a solution of N-((ls,4s)-4-aminocyclohexyl)-2-(3′-(((3S,5R)-3,5-dimethylpiperazin-l- yl)methyl)-4′-hydroxybiphenyl-3-yloxy)-5-fluoronicotinamide (100 mg, 0.17 mmol) in dry DMF (5 mL) under nitrogen was added DIPEA (0.057 mL, 0.34 mmol) at RT. The solution was stirred until homogeneous. To this solution was added dropwise a solution of IH- benzo[d]imidazole-4-carboxylic acid (27.8 mg, 0.17 mmol) and l,l’-carbonyldiimidazole (27.8 mg, 0.17 mmol) in dry DMF (5 mL) under nitrogen which had been allowed to stir at 40 0C for 1 h. The reaction mixture was allowed to stir at 50 0C overnight. The mixture was evaporated to dryness and the residue dissolved in chloroform (15 mL) and washed with saturated NaHCO3 (aq), water, dried (MgSO4) and evaporated to give a yellow oil. This was
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1H-Benzimidazole-7-carboxylic acid, its application will become more common.
Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2009/144494; (2009); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem