93668-43-0, name is 2-(1H-Imidazol-1-yl)ethanamine dihydrochloride, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: 2-(1H-Imidazol-1-yl)ethanamine dihydrochloride
To a stirred solution of 2-(1H-imidazol-1-yl)ethan-1-amine dihydrochloride (commercially available from Sigma Aldrich) (600 mg, 3.25 mmol) in DMF (5 mL) was added DIPEA (2.2 mL, 13.0 mmol) at 0 C. After 15 min, tert-butyl N-[(1E)-{[(tert-butoxy)carbonyl]amino}(1H-pyrazol-1-yl)methylidene]carbamate (commercially available from Sigma Aldrich) (1.1 g, 3.58 mmol) was added at the same temperature and allowed to stir at RT for 16 h. N2 gas was bubbled into the reaction mixture for 15 minutes then water was added to the crude product followed by stirring for 5 minutes. The resulting precipitate was filtered, washed with water (2 x 10 mL) and dried under high vacuum affording a white solid (800 mg, 71%). M/z 354.2 [M+H]+
The synthetic route of 93668-43-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Antabio SAS; DAVIES, David; LEIRIS, Simon; (56 pag.)EP3572411; (2019); A1;,
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