Adding a certain compound to certain chemical reactions, such as: 378203-86-2, name is Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, belongs to imidazoles-derivatives compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 378203-86-2, HPLC of Formula: C7H9N3O4
Intermediate 44b) A degassed solution of intermediate 44a (480 mg), 2-bromo-1 ,4-dimethoxybenzene (1.04 g), palladium acetate (54 mg), di(1 -adamantyl)-n-butylphosphine (130 mg) and potassium acetate (490 mg) in N,N- dimethyl acetamide (7 mL) was stirred under an argon atmosphere at 150 C for 2 h. The volatiles were removed under reduced pressure and the residue was dissolved in water and was extracted with CH2CI2. The combined organic layers were dried and the volatiles were removed under reduced pressure. The residue was purified by column chromatography (Si02/ 50 g, Cy / 2-propanol) to yield the desired compound (31 % yield). LC-MS {Method 1): m/z [M+H]+ = 336.2 (MW calc. = 335.31 ); R, = 3.4 min
At the same time, in my other blogs, there are other synthetic methods of this type of compound, Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, and friends who are interested can also refer to it.
Reference:
Patent; GRUeNENTHAL GMBH; NORDHOFF, Sonja; WACHTEN, Sebastian; KLESS, Achim; VOSS, Felix; RITTER, Stefanie; WO2014/108336; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem