Related Products of 66247-84-5,Some common heterocyclic compound, 66247-84-5, name is (1H-Imidazol-4-yl)methanamine hydrochloride, molecular formula is C4H8ClN3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 119A N-((1H-imidazol-4-yl)methyl)-1-(4-(2,4-difluorophenoxy)-3-(7-methoxy-1-methyl-1H-pyrrolo[2,3-c]pyridin-3-yl)phenyl)methanamine [1125] To a suspension of 1H-imidazol-4-ylmethylamine dihydrochloride (269 mg, 1.59 mmol) in a mixture of dichloromethane (3 mL) and methanol (1 mL) was added triethylamine (0.442 mL, 3.17 mmol). After stirring the mixture for five minutes, Example 105B (125 mg, 0.317 mmol) and acetic acid (0.181 mL, 3.17 mmol) were added. The mixture was heated at 50° C. for 1 hour. The mixture was cooled in an ice bath and sodium triacetoxyborohydride (134 mg, 0.634 mmol) was added portionwise over several minutes. After 15 minutes, the ice bath was removed and the reaction mixture was stirred 2 hours while warming to ambient temperature. The reaction mixture was quenched with 1 M sodium hydroxide (2 mL) and partitioned between saturated aqueous sodium bicarbonate solution (50 mL) and ethyl acetate (50 mL). The organic layer was dried over anhydrous sodium sulfate, filtered, and concentrated. The residue was purified by flash column chromatography (silica gel, 0-10percent 7N methanolic ammonia in methylene chloride) to provide the title compound (90.3 mg, 62percent yield).
The synthetic route of 66247-84-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Wang, Le; Pratt, John; Hasvold, Lisa A.; Liu, Dachun; Dai, Yujia; Fidanze, Steven D.; Holms, James H.; Mantei, Robert A.; McDaniel, Keith F.; Sheppard, George S.; McClellan, William J.; US2014/275026; (2014); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem