Application of 378203-86-2,Some common heterocyclic compound, 378203-86-2, name is Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, molecular formula is C7H9N3O4, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A degassed solution of intermediate 44a (480 mg), 2-bromo-1,4-dimethoxybenzene (1.04 g), palladium acetate (54 mg), di(1-adamantyl)-n-butylphosphine (130 mg) and potassium acetate (490 mg) in N,N-dimethyl acetamide (7 mL) was stirred under an argon atmosphere at 150 C. for 2 h. The volatiles were removed under reduced pressure and the residue was dissolved in water and was extracted with CH2Cl2. The combined organic layers were dried and the volatiles were removed under reduced pressure. The residue was purified by column chromatography (SiO2/50 g, Cy/2-propanol) to yield the desired compound (31% yield). [0596] LC-MS (Method 1): m/z [M+H]+=336.2 (MW calc.=335.31); Rt=3.4 min.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route Ethyl 1-methyl-4-nitro-1H-pyrazole-3-carboxylate, its application will become more common.
Reference:
Patent; Gruenenthal GmbH; Nordhoff, Sonja; Wachten, Sebastian; Kless, Achim; Voss, Felix; Ritter, Stefanie; US2014/194452; (2014); A1;,
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