Related Products of 4919-03-3,Some common heterocyclic compound, 4919-03-3, name is 1H-Imidazol-4-amine, molecular formula is C3H5N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
A method for the synthesis of 4-nitroimidazole by oxidation with 4-aminoimidazole is described in detail below: Step S1, Oxidation: 83 g of 4-aminoimidazole were added to the flask, followed by 750 g of waterAnd 700 g of potassium peroxymonosulfate at 35 C for 16 hours; Step S2, extraction:The reaction solution was extracted with methylene chloride to give a methylene chloride layer; in Step S3,The dichloromethane layer was subjected to distillation under reduced pressure at a temperature of 30 C and a degree of vacuum of 0.07 MPa, and dichloromethaneMethane evaporated, the remaining material is 4-nitroimidazole. The content of 4-nitroimidazole was detected94.8%, and the yield was 92.4%.
The synthetic route of 4919-03-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Anhui National Star Biochemical Co; Wei, Yongfei; Liang, Xichen; Fang, Hongxin; Huang, Chengqiang; Wu, Zongming; Wang, Xiaosheng; (6 pag.)CN106008353; (2016); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem