Reference of 29518-68-1,Some common heterocyclic compound, 29518-68-1, name is 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, molecular formula is C9H11N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Under argon protection, [RuCl2(C6H6)] 28.2 mg (0.0164 mmol) and (S)-SEGPHOS 20 mg (0.0328 mmol) was suspended in 2 ml of argon gas degassed DMF.Stir at 100 C for 1 hour; The solvent was removed under vacuum at 50 C. Obtained a brown solid; Then, add beta-bimaH 5.3 mg (0.0328 mmol) and2.6 ml of argon gas degassed DCM (dichloromethane)-methanol mixed solvent (DCM:methanol = 10:3),Then add Et3N9.9mg (0.0984mmol),Stir at room temperature for 12 hours under argon protection; The solvent was removed in vacuo, 3 mL DCM was added and filtered.The filtrate was concentrated under reduced pressure to about 0.5 ml.Add 3 ml of n-hexane to precipitate, filter, wash twice with 3 mL of diethyl ether, and dry in vacuo.The product was obtained in 23.3 mg (yield 76%).
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 2-(1H-Benzo[d]imidazol-2-yl)ethanamine, its application will become more common.
Reference:
Patent; Zhongshanyi Antai Pharmaceutical Technology Co., Ltd.; Ke Lisidian·A·shanduofu; Xu Liang; Pa Telike·boermate; A Shenli·woke; (18 pag.)CN103889995; (2016); B;,
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