Synthetic Route of 139481-69-9, A common heterocyclic compound, 139481-69-9, name is Methyl 1-((2′-(2H-tetrazol-5-yl)-[1,1′-biphenyl]-4-yl)methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate, molecular formula is C25H22N6O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
50 grams of methyl 2-ethoxy-1-[[2′- (1 H-tetrazol-5-yl) biphenyl-4-yl]-methyl]benzimidazole-7-carboxylate, 100 ml of N, N-dimethylformamide, 22.6 grams ofbenzylbromide and 45.7 grams of potassium carbonate were charged in a roundbottom flask. The reaction mass was heated to about 60-65C and stirred forabout 1-3 hours followed by cooling to about 25-30C. Reaction mass wasquenched with a mixture of sodium chloride (100 grams) and water (1 litre) understirring. Reaction mass was extracted with 2×250 ml and was washed with 2x250ml water. Organic and aqueous layers were separated and evaporated the solventcompletely by distillation at about 35-40C
The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.
Reference:
Patent; DR. REDDY’S LABORATORIES LTD.; DR. REDDY’S LABORATORIES, INC.; WO2006/15134; (2006); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem