Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 24134-65-4, name is 1,3-Dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-sulfonyl chloride, A new synthetic method of this compound is introduced below., Application In Synthesis of 1,3-Dimethyl-2-oxo-2,3-dihydro-1H-benzo[d]imidazole-5-sulfonyl chloride
Take 1,3-dimethyl-2-oxo-2,3-dihydro-1H-benzo [d] imidazole-5-sulfonyl chloride (0.5 g, 1.9 mmol),(1-benzylpiperidin-4-yl) methylamine (0.4 g, 1.9 mmol),Triethylamine (0.4g, 3.8mmol) was added to the eggplant-shaped bottle, and then dichloromethane was added, and the reaction was performed at room temperature for 6 hours;After the reaction, add water, wash with brine 3 times, spin dry, and pass through the column.A white solid was obtained with a yield of 76%.TLC detected one point, there was fluorescence at 254nm and no fluorescence at 365nm.
The synthetic route of 24134-65-4 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; China Pharmaceutical University; Sun Haopeng; Mo Jun; Li Qihang; Yang Hongyu; Chen Yao; Chen Tingkai; Li Qi; Guo Yan; Liu Zongliang; Feng Feng; Liu Wenyuan; (19 pag.)CN110776494; (2020); A;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem