Synthetic Route of 914306-50-6,Some common heterocyclic compound, 914306-50-6, name is 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole, molecular formula is C21H24N2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
In a 500 ml round bottom flask flushed with argon were introducedIrCl3.xH20 (6.48 g, 18.3 mmol) and l-(2,6-diisopropylphenyl)-2-phenyl-lH- imidazole ligand (16.74 g, 55 mmol) followed by addition of 356 ml of a 3: 1 (v/v) mixture of 2-ethoxy-ethanol and water. The resulting mixture was outgassed and heated under stirring at reflux for 21h. After cooling, the precipitate was filtered off with suction, washed with methanol and dried under vacuum. The reaction yield was 84 %.2nd step: preparation of a fac-isomer of the metal complex of formula (IV)A fac-isomer of the metal complex of formula (IV) was obtained in an identical manner to Example 1 except that l-(2,6-diisopropylphenyl)-2-phenyl- lH-imidazole was used as ligand instead of l-(2,6-dimethylphenyl)-2-phenyl- lH-imidazole. The fac-isomer yield estimated, as in example 1, from NMR analysis of the recovered precipitate is equal to 85 %; no mer-isomer was detected.
The synthetic route of 914306-50-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; SOLVAY SA; VAN PEE, Veronique; CATINAT, Jean-Pierre; WO2012/84219; (2012); A1;,
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