Related Products of 26530-93-8,Some common heterocyclic compound, 26530-93-8, name is 1-Methyl-1H-benzo[d]imidazol-6-amine, molecular formula is C8H9N3, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example No. 148Preparation of (8-Methoxy-2H-pyrazolo [3 , 4-c] quinolin-4-yl) – (3- methyl-3H-benzoimidazol-5-yl) -amine4-chloro-8-methoxy-2- (4-methoxybenzyl) -2H-pyrazolo [3,4- c]quinoline (0.16 mmol) and l-methyl-lH-benzoimidazol-6-amine (2 eq.,0.3 mmol) were suspended in MeOH (dry, 3mL) in a microwave vial (2-5mL) , HC1 in dioxane (4M, 3 drops) was added. The reaction mixture was irradiated in a microwave reactor for 5 min at 140 °C. The reaction mixture was evaporated and used without further purification. The residue was dissolved in TFA (3mL) . The reaction mixture was irradiated in a microwave reactor for 5 min at 140°C. The reaction mixture was concentrated and purified by semi- preparative HPLC-MS and freeze dried from water/t-BuOH 4/1. exact mass: 344.1599 g/mol HPLC-MS: analytical method Brt: 1.518 min – found mass: 345.1 (m/z+H)
The synthetic route of 26530-93-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ORIGENIS GMBH; ALMSTETTER, Michael; THORMANN, Michael; TREML, Andreas; KOESTLER, Roland; YEHIA, Nasser; WO2012/143143; (2012); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem