Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 31250-80-3, name is 1-Benzyl-2,4,5-tribromo-1H-imidazole, A new synthetic method of this compound is introduced below., HPLC of Formula: C10H7Br3N2
Reflux a mixture of [1-BENZYL-2,] 4, [5-TRIBROMOIMIDAZOLE] (1.043 g, 2.42 mmol), 2,4- difluorophenyl boronic acid (0.682 g, 4.32 mmol), palladium acetate (0.027 g, 0.12 mmol), R (+) -2, 2′-bis [(DI-P-TOLYL-PHOSPHINO) 1, 1′-BINAPHTHYL] (0.098 g, 0.14 mmol), 2 M sodium carbonate (3.6 [ML,] 4.83 mmol), methanol (3.6 [ML)] and toluene (36 mL) for [18] hours. Cool to ambient temperature and dilute with ethyl acetate. Wash with saturated sodium carbonate, saturated sodium chloride, dry with magnesium sulfate and purify the residue on silica gel eluting with hexane/ethyl acetate mixtures to provide [1-BENZYL-4,] 5- [DIBROMO-2- (2, 4-DIFLUORO-PHENYL)-LH-IMIDAZOLE] (0.39 g). MS [(ES+)] : [NILZ] = 461.1 (M+H) [+]
The synthetic route of 31250-80-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; ELI LILLY AND COMPANY; WO2004/14900; (2004); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem