Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 914306-50-6, name is 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole, A new synthetic method of this compound is introduced below., Safety of 1-(2,6-Diisopropylphenyl)-2-phenyl-1H-imidazole
Preparation of compound (15):0.39 g (1 .1 1 mmol) of iridium(lll) chloride trihydrate are dissolved in 1 1.5 ml of an argon-sparged solution consisting of three parts of 2-ethoxyethanol and one part of demineralized water, and also 0.71 g (2.33 mmol, 2.1 eq) of 1 -(2′,6′-di- isopropylphenyl)-2-phenyl-7/-/-imidazole (synthesized analogously to Example 14 in WO 2006/12181 1 ) at room temperature while stirring. The dark green solution is refluxed. Shortly after attainment of reflux, a yellow substance precipitates out. After reaction overnight, the pale yellow suspension cools down and is filtered off with suction. The residue which had been washed with methanol and finally with n-pentane was vacuum-dried at 50C to obtain 0.76 g (82% yield) of the product (15).1H NMR (CD2CI2, 400 MHz): delta = 0.93 (d, 3H), 1.17 (d, 3H), 1.25 (d, 3H), 1 .32 (d, 3H), 2.81 (m, 2H), 6.07 (d, 1 H), 6.23 (d, 1 H), 6.37 (dd, 1 H), 6.51 (dd, 1 H), 6.95 (s, 1 H), 7.39 (m, 2H), 7.56 (d, 1 H), 7.65 (s, 1 H).
The synthetic route of 914306-50-6 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BASF SE; BASF (CHINA) COMPANY LIMITED; MOLT, Oliver; LENNARTZ, Christian; DORMANN, Korinna; FUCHS, Evelyn; GEssNER, Thomas; LANGER, Nicolle; WATANABE, Soichi; SCHILDKNECHT, Christian; WAGENBLAST, Gerhard; WO2012/20327; (2012); A1;,
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