Related Products of 84243-58-3, A common heterocyclic compound, 84243-58-3, name is 6-(4-(1H-Imidazol-1-yl)phenyl)-4,5-dihydropyridazin-3(2H)-one, molecular formula is C13H12N4O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
EXAMPLE 4 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone Bromine (1.6 ml) is added dropwise to a solution of 4,5-dihydro-6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone (3.5 g) in acetic acid (25 ml) at 80 C. The mixture is heated for 5 to 6 hours to complete the reaction. The solid is filtered, washed with ether and converted to the free base which is crystallized from ethanol to yield 1.1 g of the product 6-[4-(1H-imidazol-1-yl)phenyl]-3(2H)-pyridazinone: mp. 244-245 C. Anal. calcd for C13 H10 N4 O.1/5H2 O; C, 64.56; H, 4.30; N, 23.17; H2 O, 1.49. Found; C, 64.30; H, 4.36; N, 23.04; H2 O, 1.11.
The synthetic route of 84243-58-3 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; Warner-Lambert Company; US4353905; (1982); A;,
Imidazole – Wikipedia,
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