Application of 72459-45-1,Some common heterocyclic compound, 72459-45-1, name is 1-(2-Bromobenzyl)-1H-imidazole, molecular formula is C10H9BrN2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
1- (2-Bromo-benzyl) -1H-imidazole (20 g, 84.0 mmol),Palladium acetate (500 mg),Triphenylphosphine (500 mg),Potassium carbonate (23 g, 167 mmol) was dissolved in DMSO (200 mL)The mixture was heated to 140 C under nitrogen for 2 hours.LC-MS showed the reaction was complete,The reaction solution was concentrated to dryness,The residue was dissolved in ethyl acetate (200 mL)Water (2 × 100 mL),Saturated brine (50 mL).Organic phase filtration,concentrate.The residue obtained 5H- imidazo [5,1-a] isoindole (10.0 g) was purified by flash silica gel column.
These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(2-Bromobenzyl)-1H-imidazole, its application will become more common.
Reference:
Patent; Shanghai Hansen Bio-pharmaceutical Technology Co., Ltd.; Jiangsu Haosen Pharmaceutical Group Co., Ltd.; Tong Chaolong; Bao Rudi; Li Yuannian; (67 pag.)CN107312005; (2017); A;,
Imidazole – Wikipedia,
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