Application of 115576-91-5, A common heterocyclic compound, 115576-91-5, name is (1-Methyl-1H-benzo[d]imidazol-5-yl)methanol, molecular formula is C9H10N2O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Example 11C : [1-METHYLBENZIMIDAZOLE-5-CARBOXALDEHYDE] A solution of 5-hydroxymethyl-1-methylbenzimidazole (0.8 g, 4 mmol) in acetone (40 [ML)] was treated with [MN02] (4 g) and the mixture was stirred for 3 days. The solid was filtered off and the solvent removed under reduced pressure to give 0.63 g of product. [COHGN2O] Mass (calculated): [160]; (found): [M+H+] = 161. NMR (400 [MHZ, DMSO-D6)] : 3.95 (3H, s, NCH3) ; 7.8 [(1H,] d, J = 8 Hz, aryl-H); 7.9 [(1H,] dd, [J =] 1 and 8 Hz, aryl-H); 8.3 [(1H,] d, J= 1 Hz, aryl-H); 8.45 [(1H,] s, imidazole-H); 10.1 [(1H,] s, CHO).
The synthetic route of 115576-91-5 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AMGEN, INC.; WO2003/99814; (2003); A1;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem