78597-27-0, name is 6-Iodo-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 6-Iodo-1H-benzo[d]imidazole
To a solution of (4-(3 -ethynylimidazo [1,2 -bjpyridazin-6-yl)phenyl)(4-methylpiperazin- 1- yl)methanone (30 mg, 0.089 mmol), and 5-iodo-1H-benzo[djimidazole in a mixture of THF and DMF (2:1, 1.5 mL) was added PdC12(PPh3)2 (3.0 mg, 0.004 mmol), Cul (1.6 mg, 0.0086 mmol), Et3N (1 mL) and then the reaction mixture was stirred? at room temperature for 12 h. The reaction mixture was concentrated in vacuo to dryness and the residue was purified by column chromatography (silica gel, eluent CH2C12/MeOH 95:5-9O: 10) to afford (4-(3-((1H- benzo [di imidazol-5-yl)ethynyl)imidazo [1 ,2-bjpyridazin-6-yl)phenyl)(morpholino)methanone (90 mg, 67%, AUC HPLC 99%) as a yellow solid. ?H NMR (400 MHz, DMSO-56) 5 (ppm):8.35 (s, 1H), 8.32 (d, J= 9.5 Hz, 1H), 8.21 (d, J= 8.4Hz,2H),8.20(s, 1H), 7.96(d, 1=9.5Hz, 1H),7.91 (s, 1H), 7.70(d, 1= 8.2Hz, 1H), 7.63 (d, J= 8.4 Hz, 2H), 7.49 (dd, J= 8.2, 1.2 Hz, 1H),3.79-3.32 (m, 8H); ?3C NMR (100 MHz, DMSO-d6) 5 (ppm: 168.52, 151.31, 143.81, 138.66,138.31, 137.19, 135.74, 127.84, 127.13, 126.34, 125.42, 117.50, 114,82, 112.69, 99.59,74.78, 66.04, 47.66; MS (ESI) mlz 449 [C26H20N602+Hjt
The synthetic route of 78597-27-0 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR); NACRO, Kassoum; CHENNAMANENI, Lohitha Rao; (62 pag.)WO2019/13703; (2019); A1;,
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