15965-57-8, name is 2-Chloro-7-methyl-1H-benzo[d]imidazole, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Recommanded Product: 15965-57-8
Step B: (8-Methyl-3H-l ‘-azaspiro[benzo[4,5]imidazo[2, l-b]oxazole-2,3 ‘- bicyclo[2.2.2]octan]-l ‘-yl-8-ium)trihydroborate To 2-chloro-7-methyl-lH-benzo[d]imidazole (0.65 g, 3.9 mmol) from example 10, step A, in THF (35 mL) was added n-butyllithium (1.6 mL, 3.9 mmol) dropwise at – 78C. After 45 minutes, a solution of racemic (l’-azaspiro[oxirane-2,3′- bicyclo[2.2.2]octan]-l’-yl-4-ium)trihydroborate (0.66 g, 4.29 mmol) from the reference example, in THF (10 mL) was added dropwise at -78C. The cooling bath ws removed and the reaction mixture warmed to room temperature. After 15 minutes, the mixture was heated to 75C for 2 hours and then cooled to room temperature. The reaction was quenched with water and the product was extracted with ethyl acetate (100 mL). The organics were dried with MgS04, filtered and the solvent was removed to yield the crude product. The crude material was purified by chromatography (Biotage) to yield racemic (8-methyl-3H-l’-azaspiro[benzo[4,5]imidazo[2, l-b]oxazole-2,3′-bicyclo[2.2.2]octan]-r- yl-10-ium)trihydroborate (0.40 g, 1.4 mmol, 52%). The 5-methyl regioisomer product was not observed. MS (LC/MS) R.T. = 1.90; [M+1-BH3]+ = 270.07.
The synthetic route of 15965-57-8 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; BRISTOL-MYERS SQUIBB COMPANY; COOK II, James H.; ZUSI, F. Christopher; HILL, Matthew D.; (87 pag.)WO2016/73407; (2016); A1;,
Imidazole – Wikipedia,
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