Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6953-65-7, name is (6-Chloro-1H-benzo[d]imidazol-2-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows., Recommanded Product: 6953-65-7
Step 2: synthesis of 4-(5-chloro-2-(hydroxymethyl)-1H-benzo[djimidazol-1- yl)butanenitrile (intermediate 21b) and 4-(6-chloro-2-(hydroxymethyl)-1H- benzo [dj imidazol-1-yl)butanenitrile (intermediate 21c)A mixture of (5 -chloro- 1 H-benzo [d]imidazo l-2-yl)methano 1 21 a (500 mg, 2.738 mmoles, 1 eq.), 4-bromobutyronitrile (466 mg, 1.15 eq.), cesium carbonate (1.338 g,1.5 eq.) and potassium iodide (45 mg, 0.1 eq.) in acetonitrile (5 mL) was refluxed overnight. The mixture was then cooled and filtered. The filtrate was evaporated under vacuum and the residue was treated with ethyl acetate (30 ml) and brine (20 ml). The separated organic layer was dried (Na2SO4), filtered and the solvent was evaporated under vacuum. The residue was purified by column chromatography (eluent: CH2C12:methanol from 1:0 to 15:1) to yield 732mg (54%) of a mixture containing the two regio-isomers 21b and 21c in a 1/1 ratio. This mixture was further separated by SFC to provide the pure regio-isomer 21b.
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6953-65-7.
Reference:
Patent; JANSSEN R&D IRELAND; TAHRI, Abdellah; VENDEVILLE, Sandrine Marie Helene; JONCKERS, Tim Hugo Maria; RABOISSON, Pierre Jean-Marie Bernard; HU, Lili; DEMIN, Samuel Dominique; COOYMANS, Ludwig Paul; WO2014/60411; (2014); A1;,
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