857070-66-7, name is (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol, belongs to imidazoles-derivatives compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. name: (2-Chloro-1H-benzo[d]imidazol-6-yl)methanol
A mixture of u-7 (0.0085 mol) and u-6 (0.0255 mol) was stirred at 120C for 4 hours. A 10% solution of K2C03 in water was added. The aqueous layer was saturated with K2C03 (powder). The mixture was extracted with CH2Cl2. The organic layer was separated, dried (over MgS04), filtered and the solvent was evaporated. The residue (4.1 g) was purified by column chromatography over silica gel (eluent: CH2C12/ CH30H/NH4OH 90/10/1; 15-40um). The pure fractions were collected and the solvent was evaporated, yielding 1.6 g of intermediate u-8 (59%).
The synthetic route of 857070-66-7 has been constantly updated, and we look forward to future research findings.
Reference:
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2005/58871; (2005); A1;,
Imidazole – Wikipedia,
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