Reference of 39811-07-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 39811-07-9, name is (5-Fluoro-1H-benzo[d]imidazol-2-yl)methanol, This compound has unique chemical properties. The synthetic route is as follows.
Thionyl chloride (27.5 mmol, 2 mL) was added slowly to a solution of 5-flouro-1H-benzimidazole-2-yl)-methanol) (FAS27) (0.55 g, 3.31 mmol) in dichloromethane (10 mL) at 10 C, the mixture was stirred until no presence of the starting material. The solvent was then evaporated, and the residue was triturated with dichloromethane, suction filtered, washed with dichloromethane and ether. 2-(Chloromethyl)- 5-flouro-1H-benzimidazole 45 was recovered as a brown powder in Yield 80%.
The chemical industry reduces the impact on the environment during synthesis (5-Fluoro-1H-benzo[d]imidazol-2-yl)methanol. I believe this compound will play a more active role in future production and life.
Reference:
Article; Alasmary, Fatmah A.S.; Snelling, Anna M.; Zain, Mohammed E.; Alafeefy, Ahmed M.; Awaad, Amani S.; Karodia, Nazira; Molecules; vol. 20; 8; (2015); p. 15206 – 15223;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem