Electric Literature of 20033-99-2, A common heterocyclic compound, 20033-99-2, name is 2-(Hydroxymethyl)-5-methoxybenzimidazole, molecular formula is C9H10N2O2, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.
Thionyl chloride (27.5 mmol, 2 mL) was added slowly to a solution of 5-methoxy-1H-benzimidazole-2-yl)-methanol) 26 (0.58 g, 3.31 mmol) in dichloromethane (10 mL) at 10 C, the mixture was stirred until no presence of the starting material. The solvent was then evaporated, and the residue was triturated with DCM, and suction filtered, then was washed with dichloromethane and ether. Yield 89% which 34 was recovered as a green powder.
The synthetic route of 20033-99-2 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Alasmary, Fatmah A.S.; Snelling, Anna M.; Zain, Mohammed E.; Alafeefy, Ahmed M.; Awaad, Amani S.; Karodia, Nazira; Molecules; vol. 20; 8; (2015); p. 15206 – 15223;,
Imidazole – Wikipedia,
Imidazole | C3H4N2 – PubChem